• Another important new result that has expanded the

  2020-10-09

  

  Another important new result that has expanded the range of functions of iPLA2-VIA in physiology and pathophysiology is its implication in macrophage polarization under stimulation conditions. Ashley et al. [129] described in peritoneal macrophages from Pla2g6−/− mice that the absence of iPLA2-VIA f

• More than thirty enzymes with PLA

  2020-10-09

  

  More than thirty enzymes with PLA2 activity have been described and, based on sequence similarities, they are currently classified in 16 groups, each containing several sub-groups [16]. However, based on biochemical features these enzymes are frequently grouped into six major families: secreted phos

• Taking a pragmatic approach with a

  2020-10-09

  

  Taking a pragmatic approach with a view to complete the study and because chemotherapy regimens in NETs are not standardized, we do not impose a specific regimen in both arms. However, one regimen in each arm is recommended in order to reduce heterogeneity: the ALKY-based chemotherapy arm will recei

• br Materials methods br Results br Discussion As shown by

  2020-10-09

  

  Materials & methods Results Discussion As shown by qPCR analysis, Bdnf1 expression was up-regulated by approximately fifty percent after injection of RG108. A possible explanation is that the overall methylation in promoter of exon I is decreased by the compound, therefore facilitating its

• br Acknowledgement br Introduction Human dihydroorotate dehy

  2020-10-08

  

  Acknowledgement Introduction Human dihydroorotate dehydrogenase (hDHODH), a flavin-dependent mitochondrial enzyme involved in de novo thousands of biosynthesis, is a validated therapeutic target for the treatment of autoimmune diseases such as rheumatoid arthritis and cancer [1], [2], [3]. L

• The first transcription factor TF known to interact

  2020-10-08

  

  The first transcription factor (TF) known to interact with one of the cis-acting GAREs is GAMYB protein, the expression of which is induced by GA in the aleurone doxercalciferol of barley (HvGAMYB) (Gubler and Jacobsen, 1992). GAMYB is an important regulator of endosperm functions during seed devel

• rc opiates Similarly LTD concentration dependently enhanced

  2020-10-08

  

  Similarly, LTD4 concentration-dependently enhanced AQP4 expression in astrocytes (Fig. 3). The LTD4-enhanced AQP4 expression was not affected by pranlukast but inhibited by Bay u9773, a non-selective CysLT1/CysLT2 receptor antagonist [33]. Because no selective CysLT2 receptor antagonists are current

• To be a qualified non specific CYP inhibitor used as

  2020-10-08

  

  To be a qualified non-specific CYP inhibitor used as an in vitro or in vivo screening tool to distinguish CYP involvement in the overall metabolism, a complete inhibition of the entire metabolism catalyzed by CYPs in a simple experiment is desired. Based on our results, 100 μM atipamezole can comple

• Perturbation in the cytokine network

  2020-10-08

  

  Perturbation in the cytokine network is correlated with disruption of growth hormone and glucocorticoid (GC) homeostasis (Thissen and Verniers, 1997; Sahid El-Radhi et al., 2000; Waxman and Holloway, 2009; Zhao et al., 2014), with important physiological consequences because cytokines affect the reg

• The significant CRF increase in the

  2020-10-08

  

  The significant CRF increase in the DS and the overall changes in the CRF system observed in the VM and DS during the development of sensitization suggest that this neuropeptide (and possibly urocortin) contributes to the specific molecular alterations occurring in the mesolimbic pathway that suppor

• sitagliptin phosphate Among the various neurotransmitter sys

  2020-10-08

  

  Among the various neurotransmitter systems pointed out to play a role in the mediation of defensive and antinociceptive responses elicited by environmentally aversive stimuli, the neuropeptide corticotropin-releasing factor or hormone (CRF or CRH) has attracted the interest of many researchers inves

• br Experimental section br Results

  2020-10-08

  

  Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised Z-IETD-FMK did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the production of antibodies in a patient by

• Mitochondrial DNA Isolation Kit mg The serotonin transporter

  2020-10-08

  

  The serotonin transporter gene () encodes an integral membrane protein that transports serotonin from the synaptic spaces into the presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent way. This protein is a target of psychomotor stimulants

• There have been attempts to stimulate the dopaminergic

  2020-10-08

  

  There have been attempts to stimulate the dopaminergic system to influence cognition in women around menopause who have subjective complaints about their cognition by Epperson et al. (Epperson et al., 2011, Epperson et al., 2015). In perimenopausal and postmenopausal women, Epperson et al. found tha

• It would be very useful if unphosphorylated CK

  2020-10-08

  

  It would be very useful if unphosphorylated CK1s could be prepared using an E. coli expression system without the troublesome in vitro phosphatase treatment. So far, it has been shown that coexpressed λPPase, a Mn2+-dependent protein phosphatase that can dephosphorylate phospho-Ser/Thr/Tyr [20,21],

15846 records 760/1057 page Previous Next First page 上5页 756757758759760 下5页 Last page