• Cancer patients may develop cachexia

  2021-08-19

  

  Cancer patients may develop cachexia, a deleterious wasting syndrome that is associated with muscle atrophy and has an impact on the well-being of patients and on the response to the treatment. Indeed, cachexia is a devastating and often irreversible syndrome observed in up to 80% of cancer patients

• In the SUMOylation pathway SCE as an E enzyme has

  2021-08-19

  

  In the SUMOylation pathway, SCE1 as an E2 enzyme has an important role in mediating the conjugation of SUMO to target proteins. The accumulated SUMO conjugates in plants are associated with abiotic stress responses (Castro et al, 2012). We performed a drought stress analysis on WT plants, induced by

• br Discussion and conclusion Ubiquitination

  2021-08-19

  

  Discussion and conclusion Ubiquitination and deubiquitination have emerged as important mechanisms involved in p53 management. This review revealed that various DUBs can regulate p53 or p53-Mdm2-MdmX networks. Herein, we reviewed the current progress made toward elucidating the complexities in th

• br DNA PK After sensing and binding to the

  2021-08-19

  

  DNA-PK After sensing and binding to the DSB, Ku quickly recruits DNA-PKcs to the site of the DNA break. Similar to Ku70/80, recruitment of DNA-PKcs to DSBs occurs within seconds of their creation [12]. The interaction between Ku70/80 and DNA-PKcs requires the presence of dsDNA and the complex for

• Common enzyme quantitative methods include

  2021-08-19

  

  Common enzyme quantitative methods include enzyme-linked immunosorbent assay [,] (ELISA), chemiluminescence (CLIA) [, , ] and immunochromatography []. The advantages of ELISA are cost reduction and automation, but non-specific reaction caused by HOOK effect, false positive caused by cross-contaminat

• br Author Contributions br Acknowledgments br Introduction

  2021-08-19

  

  Author Contributions Acknowledgments Introduction Many anticancer agents bind covalently to DNA, introduce bulky adducts, and inhibit DNA metabolic processes including repair, replication and transcription.1., 2., 3. Frequently, the first enzymes to encounter DNA adducts are DNA helicases.

• br Phylogenetic analysis KSTDs have rather diverse amino aci

  2021-08-19

  

  Phylogenetic analysis — Δ1-KSTDs have rather diverse amino CKI 7 dihydrochloride synthesis sequences. A sequence distance analysis using the program MEGA6 [75] of all currently biochemically characterized Δ1-KSTDs yielded a largest p-distance [76] of 0.67 (on a scale of 0-1) for the Δ1-KSTDs from

• HO-3867 receptor Introduction Formate dehydrogenase enzymes

  2021-08-19

  

  Introduction Formate dehydrogenase enzymes (FDHs) are a group of heterogeneous proteins that catalyse the reversible formate () oxidation to carbon dioxide () (Eq. (1)). These enzymes are classified in two families, one gathering the enzymes that hold no redox-active centres and another that includ

• We report here that DAPK signaling

  2021-08-19

  

  We report here that DAPK signaling pathways play significant roles in OGD-induced neuronal death. Exposure of the Pyr3 mg to OGD led to DAPK activation, which then promoted cell death through BimEL overexpression. Furthermore, DAPK-induced BimEL overexpression was mediated by inactivating ERK1/2 and

• During host cell interactions G intestinalis trophozoites up

  2021-08-19

  

  During host-cell interactions, G. intestinalis trophozoites up-regulate several cell-associated proteins, including high-cysteine membrane proteins (HCMPs) and variant surface proteins (VSPs) [8]. The parasite also releases around 200 proteins upon host-cell contact, including many proteases [9,10].

• Pharmacogenomics is the study of the

  2021-08-19

  

  Pharmacogenomics is the study of the role of the ARRY-380 in drug response. It was reported that the effectiveness of atorvastatin was affected by genetic factors.26, 27 In previous studies, there are many genetic polymorphisms related to the efficacy of atorvastatin. Cerda et al reported that SCAR

• The second constraint indicates that if the

  2021-08-19

  

  The second constraint indicates that if the relationship between two components A and B is two-way, then there are at least two connectors, one with origin A and destination B, and another connector with origin B and destination A (OCL2 of Fig. 4). Therefore, at least one output port of the first co

• Previous studies have documented that

  2021-08-18

  

  Previous studies have documented that SCFAs may elicit effects on lipid metabolism via de novo synthesis and transport. Acetate is not only used as an energy source, but is also constituted as a substrate for the cholesterol synthesis in the liver through acetyl-CoA, thus affecting plasma cholestero

• In our xenograft study Fig Fig

  2021-08-18

  

  In our xenograft study (Fig. 7, Fig. 8), we observed that DYD acts very similarly to progesterone; the initial faster tumor growth in the PGRMC1-transfected MCF7 tumor was not significant compared with that with progesterone, in Refusal Rates to the greater tumor growth observed with norethisterone

• ERK and p MAPK signaling pathways

  2021-08-18

  

  ERK and p38 MAPK signaling pathways play critical role in genesis and metastasis of melanoma (Tang et al., 2018). >50% of melanoma nm osi synthesis (Abildgaard and Guldberg, 2015) show abnormal activity of BRAF-RAS-RAF to activate MEK signal that drives the growth-promoting extracellular signal-reg

15944 records 592/1063 page Previous Next First page 上5页 591592593594595 下5页 Last page