• It has been known for some time that an oral

  2021-09-15

  

  It has been known for some time that an oral salt load given to mammals induces a much greater natriuresis than the intravenous administration of an equivalent amount of saline (Carey et al., 1976, Singer et al., 1998). In addition, oral administration of salt to rats has been reported to augmented

• br Pathophysiology of glaucoma Glaucoma is a group of optic

  2021-09-15

  

  Pathophysiology of glaucoma Glaucoma is a group of optic neuropathies defined by progressive degeneration of RGCs and their BI6727 synthesis in the optic nerve, which leads to irreversible loss of vision [3,8,9]. RGC degeneration is often significantly advanced before changes in visual acuity an

• br Results and discussion br

  2021-09-14

  

  Results and discussion Conclusions Introduction There is no effective treatment for HIV-associated neurocognitive disorder (HAND) which affects about half of the over 36 million people infected (Saylor et al., 2016). HIV can remain in the tamoxifen citrate receptor during combination antir

• The occurrence of MDR in cancer patients undergoing chemothe

  2021-09-14

  

  The occurrence of MDR in cancer patients undergoing chemotherapy can be mimicked in the laboratory by culturing cancer fexofenadine hydrochloride in the presence of chemotherapeutic drugs, thereby enforcing the evolution of acquired drug resistance. This has been described in multiple model systems

• br Introduction Lichen forming fungi LFFs have

  2021-09-14

  

  Introduction Lichen-forming fungi (LFFs) have evolved in various classes, including Arthoniomycetes, Coniocybomycetes, Dothideomycetes, Eurotiomycetes, Lecanoromycetes, Leotiomycetes and Lichinomycetes, in Ascomycota (James et al., 2006, Schoch et al., 2009a, Lumbsch and Rikkinen, 2017, Prieto et

• After brain injury adenosine levels rapidly increase

  2021-09-14

  

  After brain injury, adenosine levels rapidly increase in the brain [9,10]. As shown in our previous studies, the increased adenosine concentration acts on adenosine A2A receptors (A2ARs), increasing post-traumatic glutamate levels in the brain and exacerbating the severity of injuries [11,12]. Accor

• In conclusion atorvastatin but not pravastatin impaired gluc

  2021-09-14

  

  In conclusion, atorvastatin but not pravastatin impaired glucose utilization in C2C12 cells and glucose tolerance in HFD mice, which may be partly due to the inhibition of GLUT4 translocation in muscle cells. The decrease in the cholesterol level induced by atorvastatin may partly account for the in

• For many plasma membrane receptors including GPCRs their den

  2021-09-14

  

  For many plasma membrane receptors including GPCRs, their density on the cell-surface is finely controlled by various transcriptional, post-transcriptional and post-translational mechanisms, and is often a determinant of overall receptor function in a cell. To date, the transcriptional regulation an

• br Conclusions br Acknowledgments This study was

  2021-09-14

  

  Conclusions Acknowledgments This study was supported by funds from the National Natural Science Foundation of China (NSFC 31360245, 31460258) and the Applied Basic Research Foundation of Yunnan Province of China (2011FZ111). Introduction Acute myocardial infarction is the undoubted cause o

• br Pathological consequences of disruption in the GABA T

  2021-09-14

  

  Pathological consequences of disruption in the GABA/T current equilibrium This issue has been particularly investigated in the context of absence seizures. These seizures are non-convulsive epileptic attacks present in many generalized genetic epilepsies that are characterized by a sudden and rel

• The effects of FFAR and FFAR

  2021-09-14

  

  The effects of FFAR1 and FFAR2 activation in different tissues have been reported in several species (Hara et al., 2014). Herein, we report the first evidence for differential expression of FFAR1 and FFAR2 during the peripartal period in the liver of dairy cows that differ in liver metabolism, based

• Of the cases identified herein three

  2021-09-14

  

  Of the 52 cases identified herein, three known and 11 novel FGFR fusion partners were identified. Notably, an oligomerization domain, including coiled-coil dimerization domains similar to that seen in echinoderm microtubule associated protein like 4 gene (EML4), which is the most common ALK partner

• br FAAH mediation of fear and extinction In

  2021-09-14

  

  FAAH mediation of fear and extinction In addition to being a major target and modulator of stress, the BLA is a critical node within the neural circuitry subserving learned fear behaviors. The BLA is activated during the formation, expression, and extinction of conditioned fear memories, and dama

• br Nanoscale Cortical Actin Remodeling in Regulated Exocytos

  2021-09-14

  

  Nanoscale Cortical Actin Remodeling in Regulated Exocytosis The network of cortical NS 1738 is formed by numerous fine actin filaments, which are only about 10nm in diameter [52]. Although the microscale role of the cortical actin network in vesicle exocytosis is well established, the function of

• As for hMOF inhibitor s study Dekker and Zheng et

  2021-09-14

  

  As for hMOF inhibitor's study, Dekker and Zheng et al. synthesized MG149 (Fig. 1) as an inhibitor of Tip60 and MOF which has an IC50 value of 74 ± 20 μM and 47 ± 14 μM [31]. However, MG149 has no experimental data on hMOF in cell or in vivo. The lack of hMOF inhibitor limits the function study of hM

15846 records 570/1057 page Previous Next First page 上5页 566567568569570 下5页 Last page