• Understanding of potential mechanisms involved in the

  2018-11-06

  

  Understanding of potential mechanisms involved in the initial inherent neuronal bias of cultures and then using small molecules to alter this bias towards astrocyte lineages will enable uniform and faster processes to generate astrocytes. Here we explore the epigenetic mechanism that maintains the p

• dihydroergotamine RG cells have been generated from a variet

  2018-11-06

  

  RG cells have been generated from a variety of different sources of embryonic and adult brains, and embryonic stem cells (Conti et al., 2005; Liour and Yu, 2003; Bibel et al., 2004; Malatesta et al., 2000). In addition to isolating RG cells from human fetal tissue (Mo et al., 2007), it has recently

• In Huber et al reported the

  2018-11-06

  

  In 2007, Huber et al. reported the generation of stable transgenic human embryonic stem cell lines for identification and selection of differentiating CMs. Although the authors used the human MLC-2v promoter reporter construct, they did not characterize the atrial- or ventricular-like features of th

• Growth curve Two sets of WT and Ptp a

  2018-11-06

  

  Growth curve — Two sets of WT and Ptp4a3-KO GPCR Compound Library were independently compared using the same number of starting cells (1.2×106) on day 0 in a 24-well plate seeded with feeder cells. Wells were analyzed by flow cytometry in triplicate on days 1, 4, 8 and 11 to determine the absolute

• br Our group has utilized human fetal

  2018-11-06

  

  Our group has utilized human fetal hearts and a lineage-tracing, Isl1–cre knock-in hESC line as tools to study the developmental programs during human cardiogenesis and to examine the paracrine signaling mechanisms involved in self-renewal (Qyang et al., 2007) and lineage specification (Lui et al.

• Establishing standards for defining cardiac regeneration wou

  2018-11-06

  

  Establishing standards for defining cardiac regeneration would be useful for comparing different studies and ultimately for advancing the field. These standards should be high and broadly accepted. When using metabolic labels (for example BrdU and labeled thymidine preparations), the labeling strate

• Research into embryogenesis and nervous

  2018-11-06

  

  Research into embryogenesis and nervous system development has been instrumental to the identification of factors required for cell specification. Using information gleaned from these studies, many groups have developed induction protocols to instruct hESCs and iPSCs to become a variety of neural ce

• br Engineering cell cell adhesion to direct stem cell

  2018-11-06

  

  Engineering cell–cell adhesion to direct stem cell fate decisions The findings that we described above show that CDH2 and CDH11 play important roles in stem cell lineage specification, and therefore, could be used to develop technologies to control stem cell differentiation by exploiting cell–cel

• We identified a number of CD markers

  2018-11-06

  

  We identified a number of CD markers that are expressed in both osteoprogenitor and adipoprogenitor VX-765 and thus can be employed as core markers of the BMSCs phenotype. Our data corroborate previous studies that employed alternative technologies to identify markers for multipotent BMSCs. Compari

• XL 184 br Materials and methods br

  2018-11-06

  

  Materials and methods Acknowledgements This study was supported by the European Union Seventh Framework Programme through funding for the NEUROMICS network (F5-2012-305121 to L.S.), and the DZNE intersite project (grant to L.S.). We thank the patient for participation. Resource table. Reso

• A fourth question is whether mesenchymal

  2018-11-06

  

  A fourth question is whether mesenchymal precursors in other tissues can cross the mesodermal/neural crest lineage boundary. In this regard, mesenchymal tissues such as bone and adipose tissue are also developmentally generated by both the neural crest and mesoderm, and bone marrow and adipose-deriv

• br Experimental Procedures br Acknowledgments br Introductio

  2018-11-06

  

  Experimental Procedures Acknowledgments Introduction Histone-deacetylase-associated (HDAC-associated) DNA-binding transcription factors, including REST (also known as neuron-restrictive silencer factor [NRSF]) and coregulators such as the nuclear receptor corepressor (NCOR/Ncor1) and silenc

• Functional analysis has shown that miR p promotes the

  2018-11-05

  

  Functional analysis has shown that miR-342-5p promotes the differentiation of NSCs into INPs. Upregulation of miR-342-5p in cultured NS/PCs in vitro leads to reduced neurosphere formation and colony formation in the floating culture system and adherent culture system, respectively. Clonal analysis i

• It should be noted that even in

  2018-11-05

  

  It should be noted that even in a high-resistance material like zinc oxide, there are areas with unstable I–V curves (see Fig. 9). Most of these areas are situated at the grain boundaries of the polycrystalline material. Furthermore, ZnO as a phase of variable composition exhibits “memristive” effe

• br For the integral to be finite

  2018-11-05

  

  For the integral (8) to be finite we set the regularization parameter ξ equal to –1 at this stage. Then the Gauss integral (8) can be calculated without effort. The following simple example illustrates the regularization procedure proposed here (for ): The only irritant in our regularization pr

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