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protease inhibitor cocktail Bepridil is a multichannel block
2019-05-18
Bepridil is a multichannel blocker, suggesting that its pharmacological effects on cardiac myocytes are exerted by blocking Na [21], Ca [22], and K [23–25] channels. It has recently been reported that bepridil has a cardioprotective effect [26] by opening ATP-dependent K protease inhibitor cocktail
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br Discussion In Brugada syndrome
2019-05-18
Discussion In Brugada syndrome (BrS), ICD sigma 1 receptor is recommended for patients experiencing VF. However, up to 48% of such high-risk patients experience frequent ICD shocks [1] that result in significant sequelae such as depression, post-traumatic stress, and difficult VF termination due
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br Health research consortia in sub
2019-05-18
Health research consortia in sub-Saharan Africa present a positive outlook for the region through increased scientific capacity. New networks of African–African, African–European, and African–global partnerships provide platforms to advance crucial research domains. Such networks enable junior Afr
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br Drug resistant tuberculosis threatens to
2019-05-18
Drug-resistant tuberculosis threatens to undermine advances in tuberculosis control worldwide. Multidrug-resistant tuberculosis (MDRTB), defined as resistance to isoniazid and rifampicin, requires treatment for up to 24 months with expensive diagnostics and second-line drugs. Fewer than 15% of pat
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An incisional biopsy was undertaken Peri operative examinati
2019-05-17
An incisional biopsy was undertaken. Peri-operative examination of the lesion revealed an expansile tumor mass brownish in color with focal whitish areas (Fig. 3). The lesion could be delineated from the surrounding cortical bone, and surrounding soft tissues. Histopathologically the biopsy material
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Nademanee et al reported nine
2019-05-17
Nademanee et al. reported nine symptomatic patients with BrS who experienced VF and underwent electrophysiological study and catheter ablation [8]. The patients exhibited abnormal epicardial electrograms characterized by fragmented electrograms with a relatively low voltage ( Idiopathic ventricular
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There is strong agreement that HIV
2019-05-17
There is strong agreement that HIV prevention should focus on approaches that are evidence based, but there is disagreement about how to obtain such rigorous evidence and whether this should refer only to randomised study designs. Pickles and colleagues\' report provides a concrete example of an eff
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Transformation of sanitation related knowledge into routine
2019-05-17
Transformation of sanitation-related knowledge into routine practice is hindered by traditional mindsets and the absence of awareness and an attitude to learn. Poverty has been described as a barrier to following safe hygiene practices. Regular use of footwear is equally important for the prevention
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Se agrupan haciendo exaltaci n de la droga y del
2019-05-17
Se agrupan haciendo exaltación de la droga y del delito, tienen enemistad manifiesta con la autoridad, endiosan huge mitos populares, elevan a categoría de santos a los músicos muertos trágicamente, consideran mártires a los jóvenes muertos en enfrentamientos policiales o entre bandas rivales, recha
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thrombin inhibitors br Authorship br Conflict of interest
2019-05-17
Authorship Conflict of interest disclosure Introduction The Aurora kinases are serine/threonine protein kinases essential for regulation of normal thrombin inhibitors mitosis. Aurora kinases A (AAK) and B are overexpressed in hematologic malignancies, including acute myeloid leukemia (AML)
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br Material and methods br
2019-05-17
Material and methods Results Discussion ES-SCLC is a disease with poor prognosis. Treatment outcome has not improved significantly during the last decades despite great efforts have been made. Maintenance therapy has been tried in several clinical trials with the aim to prevent the onset of
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Friberg et al have indicated that the CHA
2019-05-17
Friberg et al. [17] have indicated that the CHA2DS2-VASc score is superior to the CHADS2 score in terms of stroke risk stratification, and the risk of stroke is extremely low among patients with a CHA2DS2-VASc score of in whom antithrombotic therapy is not beneficial and may even increase the risk o
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The diagnosis of vasovagal syncope is usually based on a
2019-05-17
The diagnosis of vasovagal syncope is usually based on a combination of careful history taking, clinical examination, and a surface electrocardiogram to exclude cardiac and non-cardiac causes of syncope [3,4]. When the etiology of syncope is uncertain, head-up tilt-table testing (HUTT) is commonly u
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A year old man was admitted to our hospital for
2019-05-17
A 49-year-old man was admitted to our hospital for SMVT treatment. He was diagnosed with DHCM at the age of 45 years in the referring hospital. His chief complaint was palpitations, and he was conscious and hemodynamically stable during the VT. A 12-lead electrocardiogram (ECG) during sinus rhythm r
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More recently Brugada et al used flecainide to identify the
2019-05-17
More recently, Brugada et al. [131]. used flecainide to identify the full extent of low-voltage electrogram activity in the anterior RV and RVOT and targeted this region for RFA. In all 14 BrS patients, RFA eliminated abnormal bipolar electrograms, normalized ST-segment elevation on right precordial
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