• The accumulation of oxidized low

  2023-01-16

  

  The accumulation of oxidized low-density lipoprotein (oxLDL) is one of the many causes of the initiation and progression of atherosclerosis (Virmani et al., 2002; Pirillo et al., 2013; Sun et al., 2016; Huang et al., 2016; Tabas, 2010). oxLDL-induced apoptosis of macrophages contributes to the forma

• br Conflict of interest br Acknowledgment The authors gratef

  2023-01-16

  

  Conflict of interest Acknowledgment The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China (81070220 and 81170278), and the Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Human Provi

• The proposed method was also used to evaluate resistance

  2023-01-16

  

  The proposed method was also used to evaluate resistance to natamycin (a natural antibiotic produced by Streptomyces natalensis used for fungal control on cheese surface) of 9 fungi, including those previously mentioned as well as Phoma pinodella UBOCC-A-116004, Candida parapsilosis UBOCC-A-216002,

• Incubation of the aortic segments of rats with indomethacin

  2023-01-16

  

  Incubation of the aortic segments of rats with indomethacin significantly decreased the vasoconstrictor response to Phe but only in HgCl2-treated group (Fig. 9A,B), as indicated by dAUC values (Fig. 9E). Co-treatment with losartan once again proved to be effective and prevented the increased partici

• On the contrary Birrel and colleagues observed divergent

  2023-01-16

  

  On the contrary, Birrel and colleagues observed divergent proliferative responses to androgens in different BC cell lines: DHT and mibolerone were found to inhibit the T47-D and ZR-75-1 NHS-12-Biotin growth, while the proliferation of MCF-7 cells was increased by both the androgens [53]. It is worth

• In view of the ubiquitous

  2023-01-14

  

  In view of the ubiquitous distribution of the arachidonate 12S-lipoxygenase isoforms and the variety of cellular reactions influenced by the resulting arachidonate metabolites, these products widely play important roles in many biological systems. The development of new type-specific inhibitors of t

• The most widely recognized effects of adenosine

  2023-01-14

  

  The most widely recognized effects of adenosine are operated through inhibiting A1R, one of the most abundant G protein-coupled receptors in bibf tissue [53]. A1R are located presynaptically, postsynaptically and nonsynaptically [54]. Effect of adenosine in neuronal circuits of adult mammals is to

• Molecular docking is widely used to predict

  2023-01-13

  

  Molecular docking is widely used to predict the interaction between an enzyme and its inhibitors. This is a computational simulation approach that can be used as a tool to investigate the structure-activity relationship of ACE inhibitory peptides (Goodsell, 2009). It has been recently shown that ACE

• Bioactive peptides contain amino acids with possible bioacti

  2023-01-13

  

  Bioactive peptides contain 2–20 amino acids with possible bioactivities including antihypertensive, antioxidant, antimicrobial, anticancer, and opioid activity [9], [10], [11]. There has been a great interest in antihypertensive peptides for their efficiency in lowering blood pressure. The antihyper

• It has been reported that leukotrienes and

  2023-01-13

  

  It has been reported that leukotrienes and their receptors, e.g. the cysteinyl leukotriene receptor 1 (CysLT1) may promote [D-Lys3]-GHRP-6 receptor injury (Ding et al., 2007) and that increased 5-LOX expression and activity lead to production of brain-toxic molecules (Khan et al., 2010). However, d

• br Acknowledgments br Protein microarrays were developed

  2023-01-11

  

  Acknowledgments Protein microarrays were developed to provide miniaturized high-throughput tools to study protein function, LGX818 and post-translational modifications. Just a few years ago, the seminal work performed in Stuart Schreiber's laboratory at Harvard University () and at Michael Snyd

• br Acknowledgments br Protein microarrays were developed

  2023-01-11

  

  Acknowledgments Protein microarrays were developed to provide miniaturized high-throughput tools to study protein function, LGX818 and post-translational modifications. Just a few years ago, the seminal work performed in Stuart Schreiber's laboratory at Harvard University () and at Michael Snyd

• br Conclusion We have identified three non

  2023-01-10

  

  Conclusion We have identified three non-competitive inhibitors of the human and porcine APN with Ki values in the μM range, by combining virtual screening and kinetic assays. Molecular docking simulations suggest these novel inhibitors block APN activity by an alternative mechanism to Zn coordina

• N1-Methylguanosine-5'-Triphosphate australia A disfun o

  2023-01-10

  

  A disfunção cognitiva pós‐operatória é uma síndrome perioperatória bem reconhecida, consequência da anestesia e cirurgia cuja causa exata permanece por esclarecer. De que forma N1-Methylguanosine-5'-Triphosphate australia disfunção cognitiva pós‐operatória e a doença de Alzheimer podem estar ligadas

• Recent studies demonstrated that AHR has an important role

  2023-01-10

  

  Recent studies demonstrated that AHR has an important role in the interplay between cancer metabolism and tumor-specific immunity. Tryptophan catabolism is increasingly recognized as a metabolic pathway that promotes tumorigenesis through its role in immune suppression [75]. The rate-limiting enzyme

15896 records 336/1060 page Previous Next First page 上5页 336337338339340 下5页 Last page